Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

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5,236 – 5,250 of 60,541 results

5,236

Medchemexpress LLC HY-115686 5mg , 8-Azaadenosine CAS:10299-44-2 Purity:>98%

HY-115686 5mg 8-Azaadenosine CAS: 10299-44-2 8-Azaadenosine is a potent ADAR1 inhibitor and an A-to-I editing inhibitor. 8-Azaadenosine blocks RNA editing and inhibits proliferation, 3D growth, invasion, and migration in thyroid cancer cells. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

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5,237

Medchemexpress LLC N-[(1S,2R)-1-(3-fluoro-2-methylphenyl)-1-hydroxypentan-2-yl]-2-oxo-1,3-dihydroindole-4-carboxamide | 2406205-61-4 | 99.8% | C21H23FN2O3 | 10MG

A1AT modulator 1 is a small-molecule inhibitor of Z α1-antitrypsin polymerization with reported potency (pIC50 = 8.3). The compound is supplied as a white to off-white solid for research use, has molecular formula C21H23FN2O3, molecular weight 370.42 g/mol, and an analytical purity of approximately 99.8%.

Exhibits potent inhibition of Z α1-antitrypsin polymerization (pIC50 = 8.3).
High analytical purity suitable for in vitro research.
Supplied as a solid in small milligram pack sizes for assay flexibility.
Storage recommendations provided for powder and solution to preserve stability.
Applicable to biochemical and cell-based studies of serpin modulation.

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5,238

Cayman Chemical AA92593, Purity: ≥98%, CAS: 457961-34-1, 10 mg

An OPN4 receptor antagonist (Ki = 16 nM); inhibits light-induced calcium transients in CHO cells expressing human OPN4 (IC50 = 665 nM); reverses light-induced calcium influx in rat ipRGCs at 10 µM; reduces light-induced pupil constriction in mice at 30 mg/kg

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5,239

Medchemexpress LLC 7-bromoindirubin-3-oxime | 916440-85-2 | 99.2% | 5 MG

7-bromoindirubin-3-oxime is an indirubin-derived, kinase-inhibiting research compound used in preclinical studies to probe CDK5 and GSK3β signaling and Aβ-related neurotoxicity.

Inhibits CDK5 and GSK3β, useful for kinase pathway studies.
Reported to reduce Aβ oligomer-induced neuroinflammation and synaptic impairment in models.
High purity appropriate for biochemical and cellular assays.
Stable as a solid when stored at 4°C and protected from light.
Available in small milligram pack sizes for research use.

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5,240

Cayman Chemical KY 19382, Purity: ≥95%, CAS: 2226664-93-1, 10 mg

An inhibitor of the CF5-Dvl protein-protein interaction (IC50 = 19 nM); an inhibitor of GSK3β (IC50 = 10 nM); increases expression of the mRNA encoding WISP-1 and Axin2, markers of Wnt pathway activation, in ATDC-5 chondrogenic cells at 100 nM; increases nuclear and cytosolic levels of β-catenin in ATDC-5 cells at 100 nM; increases bone plate growth and tibia length in adolescent mice at 0.1 mg/kg per day

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5,241

Apexbio Technology LLC Pindolol 100mg

B6539 is a small molecule used in biomedical research with a mode of action that has not been fully elucidated in the published literature Preliminary studies indicate that B6539 may interact with cellular signaling pathways although its precise molecular target remains to be defined The compound is utilized in experimental systems to explore its effects on cell physiology making it a potential tool for investigating novel aspects of cellular regulation and signaling Current research applications focus on elucidating its mechanism of action and evaluating its impact in various biological models

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5,242

Cayman Chemical PF-04937319 (hydrate), Purity: ≥98%, 10 mg

A glucokinase activator (EC50s = 174, 407, and 269 nM for the recombinant human, rat, and dog enzymes, respectively); increases glucose-induced insulin secretion in isolated rat islets at 4 and 12 µM; reduces postprandial plasma glucose levels in rats from 3-100 mg/kg

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5,243

Cayman Chemical KT182, Purity: ≥98%, CAS: 1402612-62-7, 25 mg

A potent inhibitor of ABHD6 (IC50s = 1.7, 15.1, and 0.24 nM in situ); brain-penetrant

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5,244

Cayman Chemical MMG-11, Purity: ≥95%, CAS: 313254-94-3, 25 mg

An antagonist of TLR1/2 (IC50 = 0.9 µM in HEK-Blue cells expressing the human receptors); selective for TLR1/2 over the TLR2/6 heterodimer (IC50 = 7.4 µM in HEK-Blue cells expressing the human receptors); inhibits Pam3CKS4-induced TNF-α and IL-6 cytokine secretion in RAW 264.7 macrophages (IC50s = 3.3 and 0.2 µM, respectively); increases SERT and GSH activity, as well as decreases LDH activity and MDA levels, in M. avium-infected Caco-2 cells at 5 ng/ml

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5,245

Cayman Chemical (2-Amino-5-bromophenyl)(pyridin-2-yl)methanone, Purity: ≥98%, CAS: 1563-56-0, 5 mg

An analytical reference standard categorized as a precursor in the synthesis of benzodiazepines; a metabolite and an acidic degradation product of bromazepam; intended for research and forensic applications

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5,246

TARGETMOL CHEMICALS INC DESOXYRHAPONTICIN 10MG

Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. 1. Desoxyrhaponticin (Deoxyrhaponticin) is an agent that is potentially effective in controlling postprandial hyperglycemia in diabetes the in vivo antidiabetic action of this compound can be explained in part at least by inhibition of glucose transport in the small intestine and inhibition of glucose reabsorption in the kidney. 2. Desoxyrhaponticin and rhaponticin could be considered as promising fatty acid synthase(FAS) inhibitors they could inhibit intracellular FAS activity and downregulate FAS expression in human breast cancer MCF-7 cells. purity: 99%

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5,247

Medchemexpress LLC PROTHIPENDYL HYDROCHLORIDE 5 mg

PROTHIPENDYL HYDROCHLORIDE 5MG

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5,248

Medchemexpress LLC MEDCHEMEXPRESS LLC

NC3957511 MIVEBRESIB-10MG

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5,249

Cayman Chemical YK-009, Purity: ≥95%, CAS: 2761458-86-8, 10 mg

An ionizable cationic lipid (pKa = 6.512); administration of SARS-CoV-2 Omicron variant mRNA in YK009-containing LNPs induces SARS-CoV-2 RBD-binding IgG in mice, with a boost in antigen-specific IgG titers 10 days after a second dose

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5,250

Cayman Chemical GW 806742X, Purity: ≥98%, CAS: 579515-63-2, 10 mg

An inhibitor of necroptosis; binds to Mlkl (Kd = 9.3 µM for the mouse protein) and decreases necroptosis induced by TNF-α, a Smac mimetic, and Q-VD-OPH in isolated mouse dermal fibroblasts at 500 nM; an inhibitor of VEGFR2 (IC50 = 2 nM); decreases VEGF-induced proliferation of HUVECs (IC50 = 5 nM); inhibits mammosphere formation by, reduces the number of extracellular actin fibers extruding from, and decreases intracellular IL-1β levels in, MDA-MB-231 cancer cells at 10 µM

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Bioactive Small Molecules

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Medchemexpress LLC HY-115686 5mg , 8-Azaadenosine CAS:10299-44-2 Purity:>98% Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC N-[(1S,2R)-1-(3-fluoro-2-methylphenyl)-1-hydroxypentan-2-yl]-2-oxo-1,3-dihydroindole-4-carboxamide | 2406205-61-4 | 99.8% | C21H23FN2O3 | 10MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 7-bromoindirubin-3-oxime | 916440-85-2 | 99.2% | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC PROTHIPENDYL HYDROCHLORIDE 5 mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC MEDCHEMEXPRESS LLC Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC HY-115686 5mg , 8-Azaadenosine CAS:10299-44-2 Purity:>98%

Medchemexpress LLC N-[(1S,2R)-1-(3-fluoro-2-methylphenyl)-1-hydroxypentan-2-yl]-2-oxo-1,3-dihydroindole-4-carboxamide | 2406205-61-4 | 99.8% | C21H23FN2O3 | 10MG

Medchemexpress LLC 7-bromoindirubin-3-oxime | 916440-85-2 | 99.2% | 5 MG

Medchemexpress LLC PROTHIPENDYL HYDROCHLORIDE 5 mg

Medchemexpress LLC MEDCHEMEXPRESS LLC